Endocrine Abstracts

Introduction: Renal transplant receivers (RTR) have a higher risk for osteoporosis, obesity and sarcopenia, which all seem to be interrelated. FGF23 and adipokine disorders, often recognized in RTR, might be involved in the fat-muscle-bone crosstalk. The current study aims to evaluate the influence of body compartiments and adipokines on bone mass in RTR.Methods: Thiscross-sectional study investigates the predictive role of body composition, adipokines (...

Published data regarding the role of FGF23 in primary hyperparathyroidism and its prognostic applicability are scarce and discordant.Aims: To assess FGF23 profile in patients with primary hyperparathyroidism undergoing surgery.Matherials and methods: Longitudinal study involving 48 patients aged 30–80 years with primary hyperparathyroidism caused by solitary parathyroid adenoma, submitted to parathyroidectomy. We evaluated FGF...

Introduction: SARS-Cov-2 infection challenged the appropriate management of acromegaly, because of delayed or limited admissions and treatment. Despite lack of data regarding SARS-Cov-2 infection in acromegalic patients (only one case reported to date), increased susceptibility to infection and poor prognosis might be triggered by the associated metabolic, cardiovascular and respiratory comorbidities. We report a series of acromegaly patients with a positive PCR test at their ...

Introduction: Lipodystrophic syndromes are rare and heterogeneous disorders characterized by the complete or partial deficiency of adipose tissue. They can be classified according to the extent of fat loss in generalized or partial subtypes and genetic or acquired based on the pathogenic mechanisms.Case report: A 37-year-old man was referred to our department with a history of nonalcoholic steatohepatitis associated with high levels of triglycerides (720...

IntroductionBody composition (BC), adipokines and the fibroblast growth factor-23 (FGF23) - Klotho axis interfere with bone metabolism and also suffer important modifications in acromegaly. We aimed to investigate their influence upon bone in active acromegaly, compared to controls.MethodsWe performed a cross sectional study, investigating the adipokines (leptin, adiponectin, resistin) secretion pattern, BC p...

Aim: Fibroblast growth factor-23 (FGF-23) has been proposed as a predictor of bone abnormalities in chronic kidney disease patients (CKD), with recent data showing that it may also predict bone mass in the general population. We aimed at investigating the relationship between FGF-23 and bone mass parameters in apparently healthy individuals, according to sex, menopausal and nutritional status.Materials and methods: Bone mass (bone mineral density-BMD, bo...